Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetics and systemic lupus erythematosus.

J M Grossman1, B P Tsao

  • 1UCLA School of Medicine, Department of Medicine, Division of Rheumatology, 1000 Veteran Avenue, Room 32-59, Los Angeles, CA 90095, USA. jgrossm an@mednet.ucla.edu

Current Rheumatology Reports
|December 21, 2000
PubMed
Summary

Genetic factors significantly influence systemic lupus erythematosus (SLE), an autoimmune disease. Research in mouse models and human association studies is identifying key genes for targeted therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artesunate inhibits type I interferon-induced production of macrophage migration inhibitory factor in patients with systemic lupus erythematosus.

Lupus·2016
Same author

Comparison of Surface Water Quality and Yields from Organically and Conventionally Produced Sweet Corn Plots with Conservation and Conventional Tillage.

Journal of environmental quality·2015
Same author

Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study.

Genes and immunity·2015
Same author

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.

Genes and immunity·2014
Same author

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.

Genes and immunity·2014
Same author

A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.

Genes and immunity·2012

Area of Science:

  • Immunology
  • Genetics
  • Autoimmune Diseases

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multifactorial origins.
  • Genetic factors are strongly implicated in the pathogenesis of SLE.

Purpose of the Study:

  • To review recent advances in understanding the genetic basis of murine and human lupus.
  • To highlight the identification of potential susceptibility genes for SLE.

Main Methods:

  • Development of congenic strains and transgenic/knock-out mouse models for murine lupus.
  • Association studies exploring MHC loci, Fcgamma receptors, cytokines, complement components, and apoptosis proteins in human lupus.
  • Linkage analyses to identify regions harboring SLE susceptibility genes.

Related Experiment Videos

Main Results:

  • Multiple murine lupus susceptibility loci have been characterized.
  • Key candidate genes and chromosomal regions associated with human lupus have been identified.
  • Ongoing studies aim to pinpoint specific genes within identified susceptibility regions.

Conclusions:

  • Understanding the genetic underpinnings of SLE is crucial for developing targeted therapeutic strategies.
  • Advances in genetic research provide a foundation for future precision medicine approaches in SLE treatment.