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Related Experiment Videos

The lung HETEs (and EETs) up.

E R Jacobs1, D C Zeldin

  • 1Departments of Medicine and Physiology, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. ejacobs@mcw.edu

American Journal of Physiology. Heart and Circulatory Physiology
|December 21, 2000
PubMed
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Cytochrome P-450 (P-450) enzymes produce eicosanoids in the lungs, impacting smooth muscle tone and ion transport. These P-450-derived arachidonate metabolites play roles in hypoxic pulmonary vasoconstriction and airway inflammation.

Area of Science:

  • Pulmonary pharmacology and physiology
  • Biochemistry of arachidonic acid metabolism

Background:

  • Arachidonic acid metabolites from cyclooxygenase and lipoxygenase pathways are crucial for lung function.
  • Cytochrome P-450 (P-450) monooxygenases are present in lung cells and may influence lung functions.

Purpose of the Study:

  • To review the presence and biological activity of P-450-derived eicosanoids in the pulmonary system.
  • To hypothesize the functions of P-450-derived arachidonate metabolites in the lungs.

Main Methods:

  • Review of recent data on P-450 eicosanoids in pulmonary vasculature and airways.
  • Discussion of emerging technologies for studying P-450 metabolites in lung function.

Main Results:

  • P-450 eicosanoids affect pulmonary vascular and bronchial smooth muscle tone.

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  • P-450 eicosanoids influence airway epithelial ion transport.
  • Hypothesized roles include hypoxic pulmonary vasoconstriction, bronchomotor tone regulation, airway fluid composition, and inflammation limitation.

    • Conclusions:

    • P-450-derived arachidonate metabolites are significant in lung physiology.
    • Emerging technologies will advance the understanding of P-450 eicosanoids in normal and pathological lung conditions.