Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normal myocardial function in severe right ventricular volume overload hypertrophy.

Y Ishibashi1, J C Rembert, B A Carabello

  • 1Gazes Cardiac Research Institute, Medical University of South Carolina, and Department of Veterans Affairs Medical Center, Charleston, South Carolina 29403, USA.

American Journal of Physiology. Heart and Circulatory Physiology
|December 21, 2000
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Physical review letters·2022
Same author

Thirty-Day Mortality for Proximal Femoral Fractures Treated at a U.K. Elective Center with a Site-Streaming Policy During the COVID-19 Pandemic.

JB & JS open access·2021
Same author

Risk factors for non-communicable diseases related to obesity among first- and second-generation Bangladeshi migrants living in north-east or south-east England.

International journal of obesity (2005)·2021
Same author

Observations of pressure anisotropy effects within semi-collisional magnetized plasma bubbles.

Nature communications·2021
Same author

Report of a Delphi exercise to inform the design of a research programme on screening for thoracic aortic disease.

Trials·2020

Severe right ventricular volume overload from tricuspid regurgitation did not impair intrinsic right ventricular contractile function. This contrasts with left ventricular dysfunction seen in mitral regurgitation.

Area of Science:

  • Cardiology
  • Physiology
  • Heart Failure Research

Background:

  • Severe left ventricular volume overload impairs myocardial contractility.
  • The impact of severe right ventricular volume overload on contractility was previously unknown.

Purpose of the Study:

  • To investigate whether severe right ventricular volume overloading leads to myocardial and cellular contractile dysfunction.
  • To compare right ventricular function in volume overload to previously established left ventricular dysfunction.

Main Methods:

  • Percutaneous creation of severe tricuspid regurgitation in seven dogs.
  • Long-term observation (3.5-4.0 years) of operated dogs.
  • Isolation and assessment of right ventricular cardiocyte sarcomere mechanics via laser diffraction.

Related Experiment Videos

Main Results:

  • Surviving dogs developed severe tricuspid regurgitation, right heart failure, and ascites, but no left heart failure.
  • Right ventricular cardiocytes from affected dogs were longer but showed no difference in shortening extent or velocity compared to controls.
  • Intrinsic right ventricular contractile function remained normal despite overt right heart failure.

Conclusions:

  • Severe right ventricular volume overload, even leading to right heart failure, does not intrinsically depress right ventricular contractile function.
  • This finding contrasts sharply with the depressed intrinsic contractile function observed in the severely volume-overloaded left ventricle due to mitral regurgitation.