Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RANTES potentiates antigen-specific mucosal immune responses.

J W Lillard1, P N Boyaka, D D Taub

  • 1Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|December 21, 2000
PubMed
Summary

The chemokine RANTES enhances adaptive mucosal and systemic immunity by boosting antibody production and T-cell responses. This suggests RANTES links innate signals to adaptive immunity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation.

Cell proliferation·2011
Same author

The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma.

Oncogene·2009
Same author

Measurement of TGF-beta in biological fluids.

Current protocols in immunology·2008
Same author

Effects of knee injection on skeletal muscle metabolism and contractile force in rats.

Osteoarthritis and cartilage·2006
Same author

Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility.

Oncogene·2006
Same author

Pharmacologic profiling of transcriptional targets deciphers promoter logic.

The pharmacogenomics journal·2005

Area of Science:

  • Immunology
  • Mucosal Immunity

Background:

  • RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) is a chemokine produced by mucosal immune cells.
  • Its role in adaptive mucosal immunity was previously uncharacterized.

Purpose of the Study:

  • To investigate the effects of RANTES on mucosal and systemic immune responses.
  • To elucidate the role of RANTES in adaptive immunity.

Main Methods:

  • Mice were nasally co-administered Ovalbumin (OVA) with or without RANTES.
  • Humoral and cellular immune responses were analyzed.
  • In vitro studies assessed T-cell activation and receptor expression.

Main Results:

  • RANTES significantly enhanced OVA-specific antibody responses in serum and mucosal secretions, including IgG subclasses.

Related Experiment Videos

  • T-cell proliferation and cytokine production (IFN-gamma, IL-2, IL-5, IL-6) were increased.
  • RANTES upregulated CD28, CD40 ligand, and IL-12 receptor expression on T cells.

    • Conclusions:

    • RANTES enhances both mucosal and systemic humoral immunity.
    • It promotes adaptive immunity through T-helper cell cytokines and costimulatory molecule induction.
    • RANTES may bridge innate and adaptive immune responses.