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Related Experiment Videos

Patch testing with methyldibromoglutaronitrile.

J Geier1, A Schnuch, J Brasch

  • 1Department of Dermatology, University of Göttengen, Germany. German Contact Dermititis Research Group. Information Network of Departments of Dermatology.

American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society
|December 21, 2000
PubMed
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Higher concentrations of methyldibromoglutaronitrile (MDBGN) with phenoxyethanol (PE) in patch testing detect more contact allergies. MDBGN 0.3% pet. may cause false positives, so MDBGN/PE 1.0% pet. is recommended for standard testing.

Area of Science:

  • Dermatology
  • Allergology
  • Cosmetic Science

Background:

  • Methyldibromoglutaronitrile (MDBGN) and phenoxyethanol (PE) are common preservatives in personal care products.
  • Increased MDBGN use correlates with rising contact sensitization rates.
  • Optimal patch testing concentrations for MDBGN allergy diagnosis are debated.

Purpose of the Study:

  • To evaluate adequate patch test concentrations for MDBGN/PE and MDBGN.
  • To determine the optimal concentration for diagnosing MDBGN contact allergy.

Main Methods:

  • The German Contact Dermatitis Research Group (DKG) conducted parallel patch tests on 4,615 patients with MDBGN/PE (0.5% and 1.0% in petrolatum).
  • Tests with MDBGN (0.1% and 0.3% in petrolatum) were performed on 988 patients.

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  • Data was collected and analyzed by the Information Network of Departments of Dermatology (IVDK).

    • Main Results:

    • MDBGN/PE 1.0% petrolatum showed a higher positive reaction rate (3.5%) compared to 0.5% (2.3%), with stable reaction index.
    • MDBGN 0.3% petrolatum yielded more positive reactions (3.3%) than 0.1% (1.4%), but with a decreased reaction index.
    • Higher concentrations increased weak positive reactions and potential for doubtful or irritant reactions with MDBGN 0.3%.

    Conclusions:

    • MDBGN/PE 1.0% petrolatum identifies additional MDBGN contact allergies missed by 0.5% concentration.
    • MDBGN 0.3% petrolatum may lead to false-positive results due to irritant reactions.
    • The DKG recommends MDBGN/PE 1.0% petrolatum for standard series and MDBGN 0.3% petrolatum only for specific cases.