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Related Experiment Videos

Primary cutaneous B-cell lymphoma in Japanese patients.

Q Liu1, K Ohshima, M Kikuchi

  • 1Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan.

Pathology International
|December 21, 2000
PubMed
Summary

This study reveals diffuse large B-cell lymphoma (DLBCL) is the most common primary cutaneous B-cell lymphoma (PCBCL) in Japanese patients, with a poorer prognosis than in European cases. Bcl-2 protein expression was common in PCBCL, regardless of lesion location.

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Leukemia & lymphoma·2016

Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Primary cutaneous B-cell lymphoma (PCBCL) is a rare lymphoproliferative disorder.
  • Limited data exists on Japanese patients with PCBCL.

Purpose of the Study:

  • To investigate clinicopathological, immunological, and molecular features of PCBCL in Japanese patients.
  • To analyze Bcl-2 gene rearrangement and protein expression in Japanese PCBCL cases.

Main Methods:

  • Clinicopathological analysis of 28 Japanese PCBCL patients.
  • Immunohistochemical analysis for Bcl-2 expression.
  • Polymerase chain reaction for Bcl-2 gene rearrangement.

Main Results:

  • Diffuse large B-cell lymphoma (DLBCL) was the most frequent subtype (25/28 cases).

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  • The 5-year survival rate for DLBCL was 61%, with leg lesions associated with poorer outcomes.
  • Bcl-2 protein expression was observed in 9/13 cases, irrespective of lesion site; no Bcl-2 gene rearrangement was detected.

    • Conclusions:

    • DLBCL is the predominant PCBCL subtype in Japan, with a worse prognosis compared to European populations.
    • PCBCL frequently exhibits Bcl-2 protein expression, suggesting a potential role independent of follicular center origin.
    • Bcl-2 expression is not site-specific in Japanese PCBCL.