Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary primitive neuroectodermal tumor of the kidney.

M Kuroda1, M Urano, M Abe

  • 1Department of Pathology, Fujita Health University, School of Medicine, Aichi, Japan. mkuro@fujita-hu.ac.jp

Pathology International
|December 21, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic inflammatory demyelinating polyneuropathy with multiple hypertrophic nerves in intracranial, and intra- and extra-spinal segments.

Internal medicine (Tokyo, Japan)·1999
Same author

Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells.

European journal of immunology·1999
Same author

Psychiatric dysfunction and dizziness.

Lancet (London, England)·1999
Same author

Focal (segmental) dyshidrosis in syringomyelia.

Journal of neurology, neurosurgery, and psychiatry·1999
Same author

Dextran restores albumin-inhibited surface activity of pulmonary surfactant extract.

Journal of applied physiology (Bethesda, Md. : 1985)·1999
Same author

[A case of pancreatoblastoma in an adult].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology·1999

This study reports a rare case of primary primitive neuroectodermal tumor (PNET) in the kidney of a 28-year-old man. The kidney PNET was successfully diagnosed and surgically removed without metastasis.

Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Primitive neuroectodermal tumors (PNETs) are rare malignant neoplasms typically affecting the central nervous system and soft tissues in children.
  • Primary PNETs of the kidney are exceptionally uncommon, with limited documented cases.

Observation:

  • A 28-year-old male presented with abdominal pain, particularly during physical activity.
  • Imaging revealed a solid lesion in the left kidney, leading to a left nephrectomy.
  • Histopathological examination showed diffuse proliferation of primitive small round cells with rosette formation.

Findings:

  • Immunohistochemistry confirmed positivity for MIC2 gene product, neuron-specific enolase, and S-100 protein.
  • The tumor was diagnosed as a primary renal PNET without evidence of metastasis.

Related Experiment Videos

  • Reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization identified the EWS-FLI1 chimera gene.

    • Implications:

    • This case expands the known spectrum of PNET presentation, highlighting the kidney as a rare primary site.
    • Early diagnosis and surgical intervention are crucial for managing primary renal PNET.
    • Genetic analysis, including EWS-FLI1 fusion detection, aids in confirming the diagnosis of PNET.