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Mobilization of hematopoietic stem cells
1Department of Internal Medicine Hematology/Oncology, Blood and Marrow Transplant Program, 601 Elmwood Avenue, Box 610, Rochester, NY 14642, USA.
Blood Reviews
|December 22, 2000
Summary
Peripheral blood stem cell transplantation offers advantages over bone marrow transplantation. This review covers hematopoietic stem cell mobilization strategies, mechanisms, and the proposed Initiation-Amplification-Emigration-Adaptation Model for improved patient care.
Area of Science:
- Hematology
- Stem Cell Biology
- Transplantation Medicine
Background:
- Hematopoietic stem cell transplantation (HSCT) is a cornerstone of modern medicine.
- Peripheral blood stem cell transplantation (PBSCT) is increasingly preferred over bone marrow transplantation due to its advantages.
- Effective mobilization of hematopoietic stem cells (HSCs) from bone marrow to peripheral blood is crucial for PBSCT.
Purpose of the Study:
- To review current advancements in hematopoietic stem cell mobilization.
- To elucidate the biology, strategies, and mechanisms of HSC mobilization.
- To introduce a novel model for understanding HSC mobilization and guiding future strategies.
Main Methods:
- Literature review of recent developments in HSC mobilization.
- Analysis of various mobilization regimens, including chemotherapy, growth factors, and combinations.
- Discussion of mobilization failure management and side effects.
Main Results:
- Several effective mobilization regimens have been developed using chemotherapeutic agents and hematopoietic growth factors.
- Understanding HSC biology is key to optimizing mobilization strategies.
- The proposed Initiation-Amplification-Emigration-Adaptation Model offers a framework for comprehending mobilization.
Conclusions:
- Peripheral blood stem cell transplantation is a valuable therapeutic approach.
- Novel mobilization strategies are continuously being developed.
- The Initiation-Amplification-Emigration-Adaptation Model can enhance the understanding and development of optimal HSC mobilization techniques for improved patient outcomes.