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Sjögren's syndrome induced by estrogen therapy
1Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel. nagler@tx.technion.ac.il
Objective:
To describe a possible role for estrogen in the induction or acceleration of Sjögren's syndrome (SS).
Method:
Two healthy young women who received estrogen-increasing therapy and then developed full-blown SS are described. The relationship between SS and estrogen therapy is discussed and the available literature reviewed.
Results:
Both women developed SS 3 years after starting estrogen-increasing treatment. The syndrome was severe in the first patient, who was treated with a high dosage of estrogen; the disease was moderate in the second patient, who received a lower estrogen dosage.
Conclusion:
Estrogen may play a role in the pathogenesis of SS in some patients.