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Choroidal neovascular membranes: reproducibility of angiographic interpretation
1Vitreous and Retina Consultants, Lakeland, Florida 33805, USA.
Purpose:
To determine interobserver agreement for classifying choroidal neovascular membranes in age-related macular degeneration.
Methods:
Six fluorescein angiograms of choroidal neovascular membranes were interpreted by 21 retina specialists. Reliability was measured by percent agreement and kappa coefficient.
Results:
Interobserver agreement of membrane types ranged from perfect concordance for a small, classic membrane to near-random classification for a complex pattern. Mean kappa coefficient was.64. Interobserver agreement of membrane size was most variable for intermediate size lesions (mean kappa coefficient =.40).
Conclusion:
Fluorescein angiographic interpretation of choroidal neovascular membrane type and size can vary considerably. Interobserver agreement is better for membrane type than for membrane size.
