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Systemic candidiasis with cataract formation in a premature infant
1Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama, USA.
Summary
Endogenous Candida endophthalmitis, a serious complication in premature infants, can rarely cause cataracts. This case highlights a severe Candida albicans infection requiring surgical intervention.
Area of Science:
- Ophthalmology
- Neonatal Medicine
- Mycology
Background:
- Endogenous Candida endophthalmitis is a known complication in premature infants, affecting up to 50% of those with systemic candidiasis.
- Systemic candidiasis occurs in approximately 3% of premature and low-birth-weight infants.
Observation:
- Typical Candida endophthalmitis involves chorioretinal lesions and vitritis.
- Lens involvement, specifically cataract formation, is exceptionally rare in these cases.
Findings:
- A premature infant with Candida albicans endophthalmitis developed a cataract.
- The infant's condition was unresponsive to systemic and intracameral antifungal treatments.
Implications:
- This case underscores the rare but severe ocular complications of Candida infections in neonates.
- Lensectomy with vitrectomy may be necessary for managing Candida-induced cataracts in infants when medical therapy fails.