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iProClass: an integrated, comprehensive and annotated protein classification database.
1Protein Information Resource, National Biomedical Research Foundation, Georgetown University Medical Center, 3900 Reservoir Road, NW Washington, DC 20007-2195, USA. wuc@nbrf.georgetown.edu
Nucleic Acids Research
|January 11, 2000
Summary
The iProClass database offers integrated protein family information, structural and functional features, and extensive cross-database links. This resource aids in protein classification and genomic research.
Area of Science:
- Bioinformatics
- Computational Biology
- Proteomics
Background:
- Protein classification is crucial for understanding biological functions.
- Existing databases like ProClass provide valuable protein family information.
- Integrated resources are needed for comprehensive protein analysis.
Purpose of the Study:
- To present the iProClass database as an integrated resource for protein family relationships and features.
- To enhance protein annotation and support genomic research.
Main Methods:
- iProClass integrates PIR superfamilies and PROSITE motifs.
- It organizes over 200,000 non-redundant proteins into superfamilies, domains, and motifs.
- The database includes links to over 30 external databases.
Main Results:
- iProClass contains over 28,000 superfamilies, 2600 domains, and 1300 motifs.
- It provides detailed annotations, including membership statistics and graphical feature display.
- The database facilitates classification-driven annotation for protein sequence databases and genomes.
Conclusions:
- iProClass serves as a valuable, integrated resource for protein family analysis.
- It supports structural and functional genomic research through comprehensive data and links.
- The database is accessible for sequence search and report retrieval.