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Related Experiment Videos

GenMapDB: a database of mapped human BAC clones.

M Morley1, M Arcaro, J Burdick

  • 1Department of Pediatrics, University of Pennsylvania, The Children's Hospital of Philadelphia, 3516 Civic Center Boulevard, ARC 516, Philadelphia, PA 19104, USA.

Nucleic Acids Research
|January 11, 2000
PubMed
Summary

GenMapDB is a public database featuring over 3000 mapped human bacterial artificial chromosome (BAC) clones. This resource aids researchers in gene mapping and chromosomal mutation analysis by providing essential positional and sequence data.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Human Genetics

Background:

  • Human bacterial artificial chromosome (BAC) clones are crucial for genomic research.
  • Mapping these clones to sequence-tagged site (STS) markers facilitates gene localization.
  • A centralized, searchable repository is needed for efficient access to this data.

Purpose of the Study:

  • To establish and maintain GenMapDB, a comprehensive database of human BAC clones.
  • To provide researchers with a tool for identifying and utilizing mapped BAC clones for genetic studies.
  • To organize and disseminate mapping data for over 3000 human BAC clones.

Main Methods:

  • Collection and curation of human BAC clone data from the RPCI-11 library.
  • Mapping of BAC clones to sequence-tagged site (STS) markers.

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  • Integration of restriction fragment analysis and end-sequence data.

    • Main Results:

    • GenMapDB contains over 3000 mapped human BAC clones.
    • The database covers 19 human chromosomes, including chromosomes 2, 4, 5, 9-22, X, and Y.
    • Positional information, restriction fragment data, and end sequences are available for each clone.

    Conclusions:

    • GenMapDB serves as a valuable resource for the research community.
    • The database facilitates gene mapping studies and chromosomal mutation analysis.
    • Free public access to GenMapDB promotes advancements in human genomics research.