The RESID Database of protein structure modifications and the NRL-3D Sequence-Structure Database

Area of Science:

• Biochemistry
• Structural Biology
• Bioinformatics

Background:

• Protein post-translational modifications (PTMs) are crucial for cellular function and are extensively studied.
• Understanding protein structure is essential for deciphering biological mechanisms.
• Existing databases often focus on specific aspects of protein information, necessitating integrated resources.

Purpose of the Study:

• To introduce and describe the RESID and NRL-3D databases.
• To highlight the comprehensive nature of the data within these resources.
• To provide accessibility information for researchers.

Main Methods:

• The RESID Database compiles annotations and structures for protein PTMs, including N-terminal, C-terminal, and cross-link modifications.
• The NRL-3D Sequence-Structure Database is derived from 3D protein structures in the Protein Data Bank.
• Both databases include systematic names, CAS registry numbers, formulas, weights, enzyme activities, taxonomic data, keywords, and literature citations.

Main Results:

• RESID provides detailed information on PTMs, encompassing chemical properties and biological context.
• NRL-3D offers standardized data on protein sequences and structures, including experimental conditions.
• Both databases are freely accessible online through the National Cancer Institute-Frederick Advanced Biomedical Computing Center and the National Biomedical Research Foundation Protein Information Resource.

Conclusions:

• The RESID and NRL-3D databases serve as valuable, integrated resources for protein research.
• These databases facilitate the study of protein modifications and structures by providing comprehensive and accessible data.
• Researchers can leverage these resources for in-depth analysis of protein function and mechanisms.