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IMGT/HLA Database--a sequence database for the human major histocompatibility complex.

J Robinson¹, M J Waller, P Parham

¹Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK.

Nucleic Acids Research

|January 11, 2000

Summary

This summary is machine-generated.

The IMGT/HLA Database provides comprehensive sequence data for human major histocompatibility complex (MHC) genes. This resource aids research in transplantation and non-infectious diseases by cataloging HLA alleles and offering analysis tools.

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Area of Science:

Immunogenetics
Genomics
Molecular Biology

Background:

The human major histocompatibility complex (MHC), known as the HLA system, is located on chromosome 6p21.3.
It comprises over 220 genes, many encoding immune system proteins, including 21 highly polymorphic HLA genes.
These HLA genes significantly impact transplantation outcomes and susceptibility to non-infectious diseases.

Purpose of the Study:

To maintain and provide access to a specialized database of polymorphic human HLA gene sequences.
To support research in immunogenetics, transplantation, and disease susceptibility.

Main Methods:

Curating and maintaining sequence data for all officially recognized HLA alleles.
Developing and offering online tools for sequence retrieval, analysis (e.g., allele reports, alignment tools), and submission.
Integrating sequences from major genetic databases (EMBL/GenBank/DDBJ).

Main Results:

The IMGT/HLA Database contains sequences for all WHO-recognized HLA alleles.
Release 1.7.0 (July 2000) includes 1220 HLA alleles from over 2700 component sequences.
Online tools facilitate data access, analysis, and submission of new sequences.

Conclusions:

The IMGT/HLA Database is a crucial resource for researchers studying the human HLA system.
The database structure serves as a model for future specialized databases for MHC genes in other species.
Continued updates and online tools enhance its utility for the scientific community.