Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RECODE: a database of frameshifting, bypassing and codon redefinition utilized for gene expression.

P V Baranov1, O L Gurvich, O Fayet

  • 1Department of Human Genetics, University of Utah, 15N 2030E Room 7410, Salt Lake City, UT 84112-5330, USA.

Nucleic Acids Research
|January 11, 2000
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A deterministic model for non-monotone relationship between translation of upstream and downstream open reading frames.

Mathematical medicine and biology : a journal of the IMA·2021
Same author

Simultaneous detection of gastrointestinal pathogens with a multiplex Luminex-based molecular assay in stool samples from diarrhoeic patients.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2013
Same author

Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction.

Open biology·2012
Same author

Theiler's murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism.

The Journal of general virology·2012
Same author

An overlapping protein-coding region in influenza A virus segment 3 modulates the host response.

Science (New York, N.Y.)·2012
Same author

Identification of A-to-I RNA editing: dotting the i's in the human transcriptome.

Biochemistry. Biokhimiia·2011

The RECODE database compiles programmed translational recoding events, including frameshifting and codon redefinition, from scientific literature. It details genetic sequences, protein products, and influencing factors for these biological mechanisms.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Translational recoding events, such as programmed ribosomal frameshifting, codon redefinition, and translational bypass, are crucial mechanisms in gene expression.
  • These events allow for the production of multiple proteins from a single gene, expanding the proteomic capacity.
  • Understanding these complex processes is vital for comprehending gene regulation and evolution.

Purpose of the Study:

  • To create a comprehensive database, RECODE, that systematically collects and organizes information on programmed translational recoding events.
  • To provide a centralized resource for researchers studying the intricacies of genetic code alteration and its biological implications.
  • To facilitate the study of the genetic sequences, encoded proteins, and regulatory elements involved in recoding.

Related Experiment Videos

Main Methods:

  • Systematic literature review and personal communications to identify programmed translational recoding events.
  • Data extraction and curation of information including gene sequences, protein sequences (normal and alternate decoding), recoding event types, trans-factors, and cis-elements.
  • Database development and population with curated data, ensuring accessibility via a web interface.

Main Results:

  • The RECODE database successfully compiles a diverse range of programmed translational recoding events from various organisms.
  • Detailed entries include genetic and protein sequences, classification of recoding events, and identified regulatory factors (trans-factors and cis-elements).
  • The database is publicly accessible, offering a valuable resource for the scientific community.

Conclusions:

  • The RECODE database serves as an essential, freely available resource for the study of programmed translational recoding.
  • It consolidates critical information, enabling deeper investigation into the mechanisms and significance of genetic code variations.
  • This compilation supports research in molecular biology, genetics, and evolutionary studies by providing structured data on recoding events.