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Related Experiment Videos

The TRANSFAC system on gene expression regulation.

E Wingender1, X Chen, E Fricke

  • 1Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany. ewi@gbf.de

Nucleic Acids Research
|January 11, 2000
PubMed
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The TRANSFAC database now includes modules for mutations, regulatory regions, and signal transduction, enhancing its utility for gene regulation research. This comprehensive system aids in identifying transcription factor binding sites and cellular regulatory networks.

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genomics

Background:

  • The TRANSFAC database is a key resource for transcription factor (TF) information.
  • Understanding TF binding sites and regulatory elements is crucial for gene expression studies.

Purpose of the Study:

  • To quantitatively extend and supplement the TRANSFAC database with new modules.
  • To provide a comprehensive system for analyzing gene regulation.

Main Methods:

  • Integration of new modules: PathoDB (pathological mutations), S/MARt DB (scaffold/matrix attached regions), TRANSPATH (signal transduction), and CYTOMER (gene expression).
  • Development of program routines for identifying TF binding sites and mapping regulatory networks.

Main Results:

Related Experiment Videos

  • The TRANSFAC system now offers expanded data on TF binding, mutations, and regulatory interactions.
  • New modules provide insights into pathologically relevant genetic variations and cellular signaling pathways.

Conclusions:

  • The enhanced TRANSFAC system provides a powerful, integrated platform for studying gene regulation.
  • The system facilitates research in molecular biology, genomics, and disease-associated genetic variations.