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Topical 0.1% indomethacin solution versus topical 0.1% dexamethasone solution in the prevention of inflammation after
L Missotten1, C Richard, C Trinquand
1Universitair Ziekenhuis, Leuven, Belgium.
Purpose:
To compare the efficacy and safety of topical 0.1% indomethacin with 0.1% dexamethasone after cataract surgery.
Methods:
145 patients (indo = 71, dexa = 74) were enrolled in a randomised, double-masked study and received one drop 4 times a day of indomethacin or dexamethasone for 1 month.
Results:
Proteinic flare and cellular Tyndall decreased with time in both groups, with a difference in favour of indomethacin for cellular Tyndall on day 30 (p = 0.046). Conjunctival hyperaemia was less pronounced in the dexamethasone group on day 30 (p = 0.03). Tolerance of both drugs was good.
Conclusion:
0.1% Indomethacin solution appears to be as safe and efficient as 0.1% dexamethasone eyedrops in the management of post-operative inflammation and could be a good alternative to the use of steroids.
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