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Local anesthetic and antiarrhythmic effect of some imidazolidin-2-one derivatives
T Librowski1, B Filipek, R Czarnecki
1Department of Pharmacodynamics, Collegium Medicum Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.
Acta Poloniae Pharmaceutica
|December 29, 2000
Abstract:
A series of the new derivatives of imidazolidin-2-one was investigated in order to determine their local anesthetic and antiarrhythmic activity. All compounds tested showed strong local anesthetic properties and variable effects on adrenaline-, aconitine- and barium chloride- induced arrhythmia. The results suggest that the antiarrhythmic properties of these compounds is related to their local anesthetic properties.