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Related Experiment Videos

Potential interventions for HIV/AIDS wasting: an overview.

D I Abrams1

  • 1Positive Health Program, San Francisco General Hospital, University of California, 94110, USA. dabrams@sfaids.ucsf.edu

Journal of Acquired Immune Deficiency Syndromes (1999)
|December 29, 2000
PubMed
Summary

Highly active therapies have reduced HIV wasting syndrome. This review covers potential therapeutic interventions and their use in managing body composition changes from antiretroviral treatments.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Metabolic Disorders

Background:

  • HIV wasting syndrome, characterized by significant weight loss and muscle atrophy, was a common complication of advanced Human Immunodeficiency Virus (HIV) infection.
  • The advent of highly active antiretroviral therapies (HAART) has dramatically decreased the incidence of HIV wasting syndrome.
  • Despite reduced prevalence, understanding and managing body composition alterations remain important aspects of HIV care.

Purpose of the Study:

  • To review existing and potential therapeutic interventions for HIV wasting syndrome.
  • To discuss the role of these therapies in managing body habitus alterations, including those induced by antiretroviral therapies.

Main Methods:

  • Comprehensive literature review of studies on HIV wasting syndrome and its treatments.

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  • Analysis of therapeutic strategies targeting cachexia and muscle wasting in the context of HIV.
  • Evaluation of interventions for managing lipodystrophy and other body composition changes associated with antiretroviral therapy.

    • Main Results:

    • While HAART has improved outcomes, some patients still experience wasting or body composition changes.
    • Various interventions, including nutritional support, anabolic agents, and anti-inflammatory drugs, have been explored with varying success.
    • Specific management strategies are needed for body habitus alterations, which can be independent of or related to viral load control.

    Conclusions:

    • HIV wasting syndrome, though less common, still requires therapeutic consideration.
    • Management strategies should encompass both nutritional and pharmacological approaches.
    • Further evaluation of specific interventions for managing body composition changes associated with antiretroviral therapy is warranted.