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[Poisoning by perazine--organ distribution and interpretation].
H Käferstein1, G Sticht, F Pluisch
1Institut für Rechtsmedizin der Universität zu Köln.
Archiv Fur Kriminologie
|December 29, 2000
Summary
A fatal perazine intoxication case in a young woman highlights severe toxicity. High drug concentrations in organs suggest a deliberate, massive overdose of Taxilan 100.
Area of Science:
- Forensic Toxicology
- Clinical Pharmacology
Background:
- Phenothiazine derivatives, like perazine, are antipsychotic medications with potential for toxicity.
- Understanding the toxicokinetics and lethal doses of specific phenothiazines is crucial for forensic investigations.
Observation:
- A fatal case of intoxication involving a 22-year-old female is presented.
- The patient had ingested a significant quantity of perazine (Taxilan 100).
Findings:
- High concentrations of perazine were detected in multiple organs, including the liver, lungs, and kidneys.
- Analytical data suggest the ingestion of 14 to 30 tablets of Taxilan 100.
- Evidence points against accidental overdose or administration by another individual.
Implications:
- This case underscores the lethal potential of perazine in massive overdose scenarios.
- Accurate toxicological analysis is vital for determining the circumstances of fatal drug intoxications.
- Findings contribute to the understanding of perazine's distribution and concentration in fatal cases.