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UV/VIS spectrophotometric methods for determination of caffeine and phenylephrine hydrochloride in complex
I Muszalska1, M Zajac, G Wróbel
1Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Science, 6 Grunwaldzka Str., 60-780 Poznań, Poland.
Abstract:
The contents of active substances were determined in a preparation TP-4 (tablets) containing paracetamol, ascorbic acid, caffeine and phenylephrine hydrochloride. For determination of caffeine and phenylephrine hydrochloride, UV/VIS spectrophotometric method was used. The VIS spectrophotometric method based on the reaction of phenylephrine with ninhydrine in sulphuric acid (1.127 kg/l). Validation of methods performed for model mixtures proved those methods were accurate, precise, repeatable and linear in the range from 50% to 150% of the amount declared in the preparation. The content of caffeine and phenylephrine hydrochloride in TP-4, Thompyrin, Panadol Extra, Ring N satisfies the FP V demands.