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The consolidation and compressibility properties of some novel directly compressible filler-binders
N Gönül1, C Oğan-Hasçiçek, T Baykara
1Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Tandoğan Sq., 06100 Ankara, Turkey.
Abstract:
The aim of this study was to investigate the consolidation and compressibility properties and also the dilution potentials of some novel directly compressible filler-binders. For this purpose, Ludipress and Cellastose 80 (one-body compounds), Tablettose 70 and Tablettose 80 (alpha-mono agglomerated lactose) were selected. They were diluted at predetermined percentages with Spherolac 100 which is a coarse sieved hydrous crystalline lactose. The consolidation and compressibility properties of the prepared powder mixtures were determined. The experimental data were evaluated by using a computer programme (Basic 80).
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