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Updated: Aug 13, 2026

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
Published on: August 21, 2013
[Centromere separation and malignancy]
1Pécsi Tudományegyetem, Altalános Orvostudományi Kar, Gyermekklinika.
Abstract:
The centromeres of human chromosomes separate according to a "normal sequence" during mitosis. "Out-of-phase" separation and especially premature centromere division may lead to aneuploidy, and may be regarded as a manifestation of chromosome instability. Evaluation of these phenomena may contribute to a better understanding of predisposition to malignancy and to the possible screening of family members at high risk of cancer. For this reason, a more up-to-date and meticulous research of regulation and clinical significance of centromere separation is warranted.
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