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Updated: Oct 10, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Water as polar modifier in normal phase chiral separation of 2-oxo-3-piperidineacetamide analogue
1Chemical Process Technologies Analytical Research, Schering Plough Research Institute, 1011 Morris Ave., Union, NJ 07083, USA. Jian.Ning@spcorp.com
Abstract:
A small amount of water present in a normal phase chiral HPLC with a Chiralcel OD column was found to be critical and necessary to separate a pharmaceutical chiral intermediate, 3-piperidineacetamide analogue. The amount of water in the normal mobile phase was optimized, and a likely mechanism of the separation was proposed.
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