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Related Experiment Videos

Acetaminophen toxicosis in the cat.

D C Finco, J R Duncan, W D Schall

    Journal of the American Veterinary Medical Association
    |March 1, 1975
    PubMed
    Summary

    Acetaminophen (N-acetyl-p-aminophenol) is toxic to cats, causing severe illness and death even at moderate doses. This common over-the-counter pain reliever poses a significant risk to feline health.

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    Human & experimental toxicology·2018

    Area of Science:

    • Veterinary Medicine
    • Toxicology
    • Pharmacology

    Background:

    • Acetaminophen (N-acetyl-p-aminophenol) is a common over-the-counter analgesic.
    • Its use in cats is not well-documented, but anecdotal reports suggest potential toxicity.
    • Phenacetin is metabolized to acetaminophen, raising concerns about its safety in cats as well.

    Purpose of the Study:

    • To investigate the toxic effects of acetaminophen in cats.
    • To determine the clinical signs and outcomes associated with acetaminophen administration in felines.
    • To assess the potential hazard of acetaminophen to cats when administered by owners.

    Main Methods:

    • Administration of varying doses of acetaminophen (325-mg tablets) to adult cats.
    • Observation and recording of clinical signs, including cyanosis, anemia, hemoglobinuria, icterus, and facial edema.
    • Monitoring of physiological parameters and outcomes, including survival.

    Main Results:

    • Oral administration of acetaminophen caused severe illness and death in cats.
    • Clinical signs included marked cyanosis due to methemoglobinemia, anemia, hemoglobinuria, and icterus.
    • Facial edema was observed in some cats, with hepatic necrosis contributing to icterus.

    Conclusions:

    • Acetaminophen is highly toxic to cats, with a narrow safety margin.
    • Over-the-counter availability of acetaminophen poses a significant risk to cats.
    • Acetaminophen toxicity in cats appears more severe and potentially more fatal than salicylates.

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