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Published on: March 3, 2021
[Clinical analysis of hypothermia in children with severe head injury]
I Takahashi1, T Kitahara, M Endo
1Department of Emergency, Teine Keijinkai Hospital, 12 chome 355, Maeda 1 jo, Teine-ku, Sapporo 006-8555, Japan.
Insights
Therapeutic hypothermia effectively reduced intracranial pressure in children with severe head injuries. While complications occurred, many patients experienced improved outcomes, suggesting its potential benefit.
Area of Science:
- Pediatric critical care medicine
- Neuroscience
- Trauma surgery
Context:
- Severe head injury in children presents significant management challenges.
- Intracranial hypertension is a critical factor influencing outcomes.
- The efficacy of therapeutic hypothermia in pediatric severe head injury remains under investigation.
Purpose:
- To evaluate the effects of therapeutic hypothermia on intracranial pressure (ICP) and patient outcomes in children with severe closed head injuries.
- To assess the safety and complication profile of prolonged hypothermia in this pediatric population.
Summary:
- This study investigated the use of therapeutic hypothermia (33-34°C) in 9 children (under 16) with severe closed head injuries.
- Hypothermia significantly reduced intracranial pressure (ICP) upon reaching target temperatures.
- Outcomes at 3-6 months showed 67% of patients had good recovery or moderate disability, while 33% had poor outcomes.
- Complications, including infections and cardiovascular dysfunction, occurred in 78% of patients during hypothermia.
Impact:
- Therapeutic hypothermia demonstrates efficacy in controlling intracranial hypertension in pediatric severe head injury.
- Despite frequent complications, hypothermia may offer a potential avenue for improving neurological outcomes in severely injured children.
- Further research is warranted to optimize the use of hypothermia and mitigate associated risks in pediatric neurotrauma.
Abstract:
Therapeutic hypothermia may improve outcome after severe head injury, but its efficacy has not been established in children with a severe head injury. The authors evaluated the effects of hypothemia (33-34 degrees C) in 9 severely closed head-injured children (under 16 years old). The cooling period was 3 to 21 days (mean 9.3). Hypothermia significantly reduced ICP when it reached 33-34 degrees C. From 3 to 6 months after injury, 6 (67%) of the 9 patients had good outcome (good recovery in 2 and moderate disability in 4), but 3 (33%) had poor outcome (severe disability in 2 and vegetative state in one). Complications, including infectious disorders (pneumonia, meningitis, sepsis), cardio-vascular system dysfunction (cardiac arrhythmia, hypotension), decreased platelet counts, hypokalemia, diabetes insipidus, acute pancreatitis occurred during hypothermia in 7 patients (78%). The results of this study suggest that treatment with hypothermia in children with severe head injury is often accompanied complications, but it is an effective method to control intracranial hypertension and may have improved the outcome.
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