Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic hitchhiking.

N H Barton1

  • 1Institute of Cell, Animal and Population Biology, University of Edinburgh, UK. n.barton@ed.ac.uk

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|December 29, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishment in a new habitat by polygenic adaptation.

Theoretical population biology·2017
Same author

The infinitesimal model: Definition, derivation, and implications.

Theoretical population biology·2017
Same author

HABITAT PREFERENCE IN THE BOMBINA HYBRID ZONE IN CROATIA.

Evolution; international journal of organic evolution·2017
Same author

THE PROBABILITY OF FIXATION OF A NEW KARYOTYPE IN A CONTINUOUS POPULATION.

Evolution; international journal of organic evolution·2017
Same author

How does epistasis influence the response to selection?

Heredity·2016
Same author

Spread of pedigree versus genetic ancestry in spatially distributed populations.

Theoretical population biology·2015
Same journal

The microlandscapes of tree trunks: the effect of lichen and tree-level characteristics on arthropod communities.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Centimetre-scale landscapes to assess the motion behaviour and cognition of gastropods and bivalves.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Intertidal microcosms of wave-swept rocky shores: ecological and physiological insights from a uniquely stressful environment.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Temporal and spatial variation in temperature and oxygen at the microscale: key niche axes for aquatic life.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Natural microcosms in ecology: fulfilling the promise of model systems?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Microbe-induced galls and plant defence: metabolite crosstalk in a co-evolutionary battle.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
See all related articles

Genetic hitchhiking occurs when selection on one gene affects neutral genes. This review explores models of hitchhiking, including fluctuating selection and spatial population structures, impacting neutral allele drift.

Area of Science:

  • Evolutionary genetics
  • Population genetics
  • Molecular evolution

Background:

  • Selection on a gene can indirectly affect other genes, even those without direct fitness consequences.
  • Genetic hitchhiking describes the phenomenon where neutral genetic variation is affected by selection on linked loci.
  • Classical models by Maynard Smith and Haigh focused on single favorable mutations, while other models considered inherited fitness variation.

Purpose of the Study:

  • To review the theory of genetic hitchhiking, focusing on its effects on neutral genetic loci.
  • To analyze a model of fluctuating selection that bridges different theoretical treatments of hitchhiking.
  • To investigate the impact of spatial population structure on genetic hitchhiking and neutral allele frequencies.

Main Methods:

Related Experiment Videos

  • Review of existing theoretical frameworks for genetic hitchhiking.
  • Analysis of a mathematical model for fluctuating selection, considering allele frequencies, selection strength, and recombination rates.
  • Examination of models incorporating spatial population structure, neighborhood size, and recombination relative to selection.

Main Results:

  • In models with strong selection and low recombination, fluctuating selection increases the rate of neutral drift.
  • In spatially structured populations, selective substitutions cause only local increases in neutral allele frequency.
  • The local increase in neutral allele frequency depends on the ratio of recombination to selection and neighborhood size.

Conclusions:

  • Spatial subdivision weakens the effects of individual selective substitutions on neutral alleles.
  • While spatial subdivision may increase the frequency of local selective sweeps, it is unlikely to significantly enhance overall neutral allele drift.
  • Understanding genetic hitchhiking is crucial for interpreting patterns of molecular evolution and genetic variation in populations.