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Primary choroid plexus carcinoma producing carbohydrate antigen 19-9
T Inamura1, S Nishio, Y Miyagi
1Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Clinical Neuropathology
|December 29, 2000
Summary
This study presents a rare case of primary choroid plexus adenocarcinoma in a 40-year-old female. The tumor produced carbohydrate antigen 19-9 (CA19-9), which decreased after surgical removal.
Area of Science:
- Neuro-oncology
- Pathology
- Biochemistry
Background:
- Choroid plexus tumors are rare intracranial neoplasms.
- Adenocarcinomas of the choroid plexus are exceptionally uncommon.
- The role of tumor markers in choroid plexus neoplasms is not well-established.
Observation:
- A 40-year-old female presented with symptoms attributed to a primary choroid plexus adenocarcinoma.
- Elevated serum levels of carbohydrate antigen 19-9 (CA19-9) were noted.
- A tumor in the left lateral ventricle was partially resected.
Findings:
- Post-surgical reduction in tumor mass led to a rapid decrease in serum CA19-9 levels.
- Immunohistochemical analysis of the resected tumor tissue showed strong CA19-9 expression.
- This case represents the first documented instance of CA19-9 production by a primary choroid plexus carcinoma.
Implications:
- Carbohydrate antigen 19-9 may serve as a potential tumor marker for primary choroid plexus adenocarcinoma.
- Further research is warranted to explore the diagnostic and prognostic value of CA19-9 in these rare tumors.
- This finding contributes to understanding the molecular characteristics and potential biomarkers of rare brain tumors.