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Updated: Aug 9, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates
Published on: November 23, 2016
Fatty acid amide hydrolase substrate specificity
D L Boger1, R A Fecik, J E Patterson
1Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA. boger@scripps.edu
Abstract:
Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH.
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