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Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex
A K Bence1, D T Rogers, D R Worthen
1Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536, USA.
Bioorganic & Medicinal Chemistry Letters
|December 29, 2000
Abstract:
As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl-D-aspartate (NMDA) receptor function. Aminoanthraquinones may represent a novel class of polyamine binding site ligands with a unique pharmacophore and may facilitate the rational design of novel NMDA-receptor modulators.