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New multidrug resistance modulators from Atractylodis Lanceae Rhizoma
N Murakami1, E Iwata, S Tamura
1Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Bioorganic & Medicinal Chemistry Letters
|December 29, 2000
Abstract:
Three new oligoacylated sucroses designated atractysucroses-I, -II, and -III were obtained from Atractylodis Lanceae Rhizoma as multidrug resistance (MDR) modulating substances against human carcinoma cell lines and their chemical structures were characterized as a mixture of acyl groups. Atractysucrose-I modulates MDR in KB-C2 cells as strongly as verapamil. This is the first example of an MDR-modulator classified as a carbohydrate.