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Updated: Oct 10, 2026
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Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
Published on: July 17, 2020
Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2
T Hamaguchi1, A Takahashi, T Kagamizono
1Medical Research Laboratories, Taisho Pharmaceutical Co., Ltd, Saitama, Japan. s14795@ccm.taisho.co.jp
Bioorganic & Medicinal Chemistry Letters
|December 29, 2000
Abstract:
The synthesis and biological activity of a series of 2-[(4-methylthiopyridin-2-yl)methylsulfinyl]benzimidazoles are described. These compounds have potent inhibitory effects against the protein tyrosine phosphatase activity of CD45. Enzymatic analysis with several phosphatases revealed that compound 5a had high specificity for CD45 compared with serine/threonine phosphatases (PP1, PP2A), tyrosine phosphatases (LAR, PTP1B and PTP-S2) and dual phosphatase (VHR).
