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Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions
Published on: July 22, 2016
Nonparametric rank-based methods for group sequential monitoring of paired censored survival data
1Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109-2029, USA. skmurray@umich.edu
Abstract:
This research gives methods for nonparametric sequential monitoring of paired censored survival data in the two-sample problem using paired weighted log-rank statistics with adjustments for dependence in survival and censoring outcomes. The joint asymptotic closed-form distribution of these sequentially monitored statistics has a dependent increments structure. Simulations validating operating characteristics of the proposed methods highlight power and size consequences of ignoring even mildly correlated data. A motivating example is presented via the Early Treatment Diabetic Retinopathy Study.
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