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Related Concept Videos

Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Estimation of k and VD of Aminoglycosides01:20

Estimation of k and VD of Aminoglycosides

Aminoglycosides are a class of antibiotics used to treat various bacterial infections. Clinicians must determine the elimination rate constant (k) and volume of distribution (VD) to optimize therapeutic efficacy and minimize toxicity. The k value represents the rate at which the drug is removed from the body, and the VD reflects the degree to which the drug distributes into body tissues. Accurately estimating these parameters allows healthcare professionals to tailor drug dosing to individual...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

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Related Experiment Video

Updated: Jul 21, 2026

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
11:28

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

Published on: September 9, 2015

Indications for vancomycin in dialysis patients.

T A Golper1, G Schulman, E M D'Agata

  • 1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

Seminars in Dialysis
|December 29, 2000
PubMed
Summary

Physicians, especially nephrologists, are not judiciously using vancomycin, leading to increased resistance in dialysis units. Overcoming complacency and practice barriers is crucial for appropriate antibiotic stewardship.

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A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
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Area of Science:

  • Infectious Diseases
  • Nephrology
  • Antimicrobial Stewardship

Background:

  • Emergence of vancomycin resistance in Staphylococcus aureus, coagulase-negative staphylococci (CNS), and enterococci.
  • High prevalence of vancomycin resistance in dialysis units.
  • Imperative need for judicious vancomycin use in clinical practice.

Purpose of the Study:

  • To highlight the critical need for appropriate vancomycin utilization.
  • To address the challenges in implementing vancomycin guidelines.
  • To underscore the impact of physician complacency and practice barriers on antimicrobial resistance.

Main Methods:

  • Review of current clinical practices regarding vancomycin use in dialysis units.
  • Analysis of factors contributing to the inappropriate use of vancomycin.
  • Discussion of the implications of physician behavior on antimicrobial resistance patterns.

Main Results:

  • Physicians, particularly nephrologists, exhibit complacency in switching from vancomycin to alternative antibiotics even when susceptibility data permits.
  • Cost constraints and bureaucratic factors exacerbate the problem of vancomycin overuse.
  • Resistance to vancomycin is increasing among pathogens common in dialysis populations.

Conclusions:

  • Urgent need for enhanced antimicrobial stewardship programs in dialysis settings.
  • Addressing physician complacency and practice inertia is vital to combat vancomycin resistance.
  • Revisiting and reinforcing guidelines for vancomycin use is essential to preserve its efficacy.