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Near fatal acute colchicine intoxication in a child. A case report
1Paediatric Department B, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
European Journal of Pediatrics
|December 29, 2000
Abstract
Unlabelled:
An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug. She developed gastrointestinal, central nervous system, cardiovascular and haematological disturbances. Over 2 months she had been drinking high doses of natural grapefruit juice which, combined with long-term colchicine therapy and a viral upper respiratory tract infection, increased her susceptibility to the drug.
Conclusion:
To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.