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Updated: Jul 28, 2026

Isolation and Derivation of Mouse Embryonic Germinal Cells
Published on: October 22, 2009
Early events in the mammalian germ line
O Anderson1, J Heasman, C Wylie
1Department of Genetics, Cell Biology and Development, University of Minnesota School of Medicine, Minneapolis 55455, USA.
Abstract:
Germ cells represent the genetic and cellular link between generations, as well as the transmitters of inherited diseases. Despite their central importance, not much is known about the molecular mechanisms whereby a germ cell lineage becomes set aside during development, or how the germ cells, once formed, migrate to the gonads and combine with somatic cells to make a gonad. This article provides a brief review of current knowledge on these issues, with particular focus on the mammalian germ line.
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