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Related Experiment Videos

Technetium-99m-diphosphonate accumulation in amyloid.

J D VanAntwerp, R E O'Mara, M J Pitt

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |March 1, 1975
    PubMed
    Summary

    This case study shows Technetium-99m-diphosphonate uptake in amyloidosis associated with multiple myeloma. This finding aids in diagnosing amyloidosis in soft tissues, especially around the hips and shoulders.

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    Area of Science:

    • Oncology
    • Radiology
    • Pathology

    Background:

    • Multiple myeloma is a plasma cell malignancy.
    • Amyloidosis is a condition characterized by amyloid protein deposition in tissues.
    • Complications of multiple myeloma can include amyloidosis, affecting various organs.

    Purpose of the Study:

    • To present a case of multiple myeloma with histologically confirmed amyloidosis.
    • To illustrate the utility of bone-seeking radiopharmaceuticals in detecting amyloid deposition.
    • To highlight amyloidosis as a diagnostic consideration in patients with unexplained arthralgia and specific radiopharmaceutical uptake patterns.

    Main Methods:

    • Histological examination to confirm amyloidosis.
    • Imaging with Technetium-99m-diphosphonate to assess radiopharmaceutical distribution.
    • Clinical correlation of imaging findings with patient symptoms.

    Main Results:

    • Histological evidence of amyloidosis in a patient with multiple myeloma.
    • Demonstration of Technetium-99m-diphosphonate uptake in areas of amyloid deposition, specifically around the shoulders and hips.
    • Identification of extraosseous sites of radiopharmaceutical accumulation without calcification.

    Conclusions:

    • Technetium-99m-diphosphonate uptake in periarticular soft tissues, particularly hips and shoulders, suggests amyloidosis.
    • Amyloidosis should be considered in the differential diagnosis of patients with multiple myeloma and undiagnosed arthralgia.
    • Radiopharmaceutical imaging provides an additional dimension for identifying extraosseous amyloid deposition.

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