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[Neurovegetative diseases in dementia].

E Navarrete1, O Prospéro, R Hudson

  • 1Departamento de Fisiología, Facultad de Medicina, UNAM, Apdo. Postal 70250México, 04510, D.F.

Gaceta Medica De Mexico
|December 29, 2000
PubMed
Summary

Dementia involves progressive neural cell death, impacting memory and learning. Early olfactory dysfunction in Alzheimer's and Parkinson's suggests potential for olfactory testing in early diagnosis.

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Area of Science:

  • Neuroscience
  • Neurology

Context:

  • Dementia encompasses neurodegenerative diseases like Alzheimer's and Parkinson's, characterized by progressive neural cell dysfunction and death.
  • Aging populations over 50 face increased dementia risk due to factors like reduced gonadal hormone levels.

Purpose:

  • To explore the pathological underpinnings of dementia and identify potential early diagnostic markers.
  • To investigate the link between specific brain region pathology and early clinical symptoms.

Summary:

  • Dementia results from central and peripheral nervous system cell death, leading to cognitive deficits. Common neurodegenerative diseases include Alzheimer's, Parkinson's, Huntington's, Pick's, and Creutzfeldt Jakob disease.
  • Pathological changes in areas like the entorhinal cortex are implicated in dementia.
  • Early olfactory dysfunction in Alzheimer's and Parkinson's disease patients, linked to entorhinal cortex affliction, suggests olfactory testing as a potential early diagnostic tool.

Impact:

  • Highlights the potential of olfactory testing for early detection of neurodegenerative diseases.
  • Emphasizes the role of aging and hormonal changes as risk factors for dementia.
  • Provides insights into the anatomical correlates of dementia symptoms.

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