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Numb chin syndrome in Ewing sarcoma
N L Antunes1, R Gorlick, E Callaja
1Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Journal of Pediatric Hematology/Oncology
|December 29, 2000
Summary
Numb chin syndrome, a chin and lower lip sensation loss, can signal advanced cancer in children. This symptom in pediatric solid tumors warrants investigation into widespread bone involvement.
Area of Science:
- Oncology
- Neurology
- Pediatrics
Background:
- Numb chin syndrome (NCS) is characterized by reduced sensation in the chin and lower lip.
- In adults, NCS often indicates metastatic disease affecting the skull base, mandible, or leptomeninges.
- In children, NCS is typically linked to leukemic cell infiltration of the inferior alveolar nerve.
Observation:
- This study presents two pediatric cases of NCS associated with Ewing sarcoma.
- Ewing sarcoma is a rare bone cancer primarily affecting children and young adults.
Findings:
- The occurrence of NCS in a child with a solid tumor, such as Ewing sarcoma, suggests a potentially grave prognosis.
- This symptom may indicate progressive skeletal involvement or metastatic disease.
Implications:
- Pediatric NCS in the context of solid tumors necessitates a thorough investigation for skeletal metastases.
- Early identification of NCS as a potential indicator of advanced disease can guide timely and appropriate treatment strategies.