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Celiac disease in India.

B R Thapa1

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Postgraduate Institute of Medical Education and Research, Chandigarh.

Indian Journal of Pediatrics
|January 2, 2001
PubMed
Summary
This summary is machine-generated.

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Celiac disease in children, particularly in India, presents with varied symptoms like chronic diarrhea and growth failure. Early diagnosis via serological tests and a gluten-free diet are crucial for effective management.

Area of Science:

  • Gastroenterology
  • Pediatrics
  • Immunology

Background:

  • Celiac disease is increasingly recognized in India, particularly Northern regions.
  • Diagnosis can be challenging due to atypical presentations and co-existing conditions like malnutrition and parasitic infections.

Purpose of the Study:

  • To highlight the diagnostic challenges and clinical manifestations of celiac disease in Indian children.
  • To evaluate the utility of serological markers and the impact of a gluten-free diet.

Main Methods:

  • Review of clinical cases and diagnostic approaches for celiac disease.
  • Assessment of serological tests including antigliadin, anti-reticulin, and endomysial antibodies.
  • Evaluation of treatment outcomes with a gluten-free diet.

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Main Results:

  • Celiac disease should be suspected in children with chronic diarrhea, growth failure, and unusual symptoms like anemia, rickets, or short stature.
  • Serological tests show promise for screening and diagnosis, though intestinal biopsies remain definitive.
  • A gluten-free diet leads to significant clinical improvement.

Conclusions:

  • Celiac disease diagnosis in India requires a high index of suspicion due to confounding factors.
  • Serological tests aid in early detection, complementing traditional biopsy methods.
  • Dietary gluten withdrawal is a highly effective treatment for celiac disease.