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Related Experiment Videos

[Candida].

I Furuta1

  • 1Department of Clinical Pathology, Kinki University School of Medicine, Osaka-sayama 589-8511.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|January 2, 2001
PubMed
Summary
This summary is machine-generated.

Candidiasis incidence has risen due to immunodeficiency and broad-spectrum antibiotic use. Candida albicans is the most frequent cause, particularly in immunocompromised patients.

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Candidiasis incidence is increasing, especially in immunocompromised patients like those with leukemia, lymphoma, and aplastic anemia.
  • Overuse of broad-spectrum antimicrobials and prolonged survival of immunodeficient patients contribute to rising candida infections.
  • Candida species are significant causes of nosocomial infections, alongside Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus.

Purpose of the Study:

  • To analyze the incidence and trends of candidiasis, focusing on common Candida species and deep-seated infections.
  • To identify the most frequent Candida species isolated from clinical samples.
  • To examine the epidemiological changes in deep-seated candidiasis and associated patient factors.

Main Methods:

Related Experiment Videos

  • Retrospective analysis of candidiasis cases and isolated Candida species.
  • Monitoring of Candida species frequency, including Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, and Candida krusei.
  • Examination of annual trends in deep-seated candidiasis in autopsied cases and correlation with patient laboratory values.

Main Results:

  • Candida albicans was the most frequently isolated species (60-70% annually), followed by C. glabrata, C. tropicalis, C. parapsilosis, and C. krusei.
  • C. albicans showed high isolation rates from sputum (66-77%), urine (43-70%), and vaginal swabs (62-72%).
  • Deep-seated candidiasis incidence peaked between 1985-1988 and subsequently declined. Stomach infections were most common, followed by esophagus, lung, and kidney. These cases were associated with low lymphocyte, neutrophil, hemoglobin, total protein, and total cholesterol levels.

Conclusions:

  • Candida albicans remains the predominant cause of candidiasis, with significant isolation rates across various sample types.
  • The epidemiology of deep-seated candidiasis has shifted, with a notable decrease after 1988.
  • Immunocompromised status, indicated by low blood cell counts and protein levels, is a critical factor in deep-seated candidiasis development.