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Circulating adhesion molecules in patients with vibration-induced white finger
1Department of Public Health, Faculty of Medicine, Tottori University, and the Vibration Syndrome Center, San-in Rosai Hospital, Yonago, Japan. kurozawa@grape.med.tottori-u.ac.jp
Angiology
|January 2, 2001
Summary
Vibration-induced white finger is linked to increased soluble vascular cell adhesion molecules. Other soluble adhesion molecules like E-selectin and intercellular adhesion molecules were not significantly different in affected individuals.
Area of Science:
- Occupational Health
- Vascular Biology
- Immunology
Background:
- Vibration-induced white finger (VWF) is a condition causing vascular damage.
- The role of soluble adhesion molecules in VWF pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the association between specific soluble adhesion molecules and vascular damage in VWF.
- To compare levels of soluble E-selectin, intercellular adhesion molecules, and vascular cell adhesion molecules in VWF patients and controls.
Main Methods:
- Serum concentrations of soluble E-selectin, intercellular adhesion molecules, and vascular cell adhesion molecules were measured.
- Sandwich enzyme-linked immunosorbent assay (ELISA) was utilized for quantification.
- Study included 35 men with vibration exposure and 40 healthy controls.
Main Results:
- Serum levels of soluble E-selectin and intercellular adhesion molecules were not significantly elevated in men with VWF compared to controls.
- A significant increase in serum levels of soluble vascular cell adhesion molecules was observed in patients with VWF.
Conclusions:
- Soluble vascular cell adhesion molecules may play a role in the vascular damage associated with vibration-induced white finger.
- E-selectin and intercellular adhesion molecules do not appear to be directly implicated in VWF development based on this study.