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A novel pyridazinone derivative as a nonprostanoid PGI2 agonist
K Tsubaki1, K Taniguchi, S Tabuchi
1Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, Osaka, Japan.
Bioorganic & Medicinal Chemistry Letters
|January 2, 2001
Abstract:
A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 microM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats.