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Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-l-aralkylpiperazines
R M Kanojia1, J J Salata, J Kauffman
1The R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869-0602, USA. rkanojia@pruis.jnj.com
Bioorganic & Medicinal Chemistry Letters
|January 2, 2001
Abstract:
The synthesis and in vitro Class III antiarrhythmic activity of several 4-aroyl (and aryl)-1-aralkylpiperazine and piperidine derivatives are described. Among several potent compounds identified in the series, RWJ-28810 (3), with its EC20 of 3 nM, ranks as one of the most potent (in vitro) compounds reported.