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Bilateral renal aspergillosis.

A B Warshawsky, D Keiller, R F Gittes

    The Journal of Urology
    |January 1, 1975
    PubMed
    Summary

    Increased use of immunosuppressants has led to more fungal infections. This report details the first case of bilateral renal aspergillosis treated successfully with surgery and antifungal drugs.

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    Area of Science:

    • Medicine
    • Infectious Diseases
    • Nephrology

    Background:

    • Rising incidence of fungal infections linked to increased use of steroids, immunosuppressants, and cytotoxic drugs.
    • Fungal infections pose significant risks, particularly in immunocompromised patients.
    • Renal involvement by fungi can lead to severe complications.

    Purpose of the Study:

    • To report the first case of bilateral renal aspergillosis without disseminated disease.
    • To describe a comprehensive treatment strategy for this rare condition.
    • To discuss the management of fungal urinary tract infections.

    Main Methods:

    • Surgical evacuation of fungal hyphae from the kidneys.
    • Parenteral administration of antimycotic chemotherapy.
    • Topical instillation of amphotericin B.
    • Use of systemic agents like 5-fluorocytosine and rifampicin.

    Main Results:

    • Successful clearance of fungal masses from both kidneys.
    • Resolution of bilateral renal aspergillosis.
    • Demonstration of a viable multitherapeutic approach for a complex fungal infection.

    Conclusions:

    • Bilateral renal aspergillosis without dissemination is a rare but treatable condition.
    • A combination of surgical and aggressive medical therapy is crucial for successful outcomes.
    • Effective management of fungal urinary tract infections requires a tailored, multidisciplinary approach.

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