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Successful treatment of hypothalamic seizures and precocious puberty with GnRH analogue
M Zaatreh1, M Tennison, R S Greenwood
1Department of Neurology and Pediatric Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. mmzid@med.unc.edu
Neurology
|January 3, 2001
Abstract:
Patients with hypothalamic hamartomas and precocious puberty may develop gelastic seizures that are resistant to conventional antiepileptic drug therapies. While treating precocious puberty in two such patients with long-acting GnRH analogue, the authors observed cessation of gelastic seizures. Although the mechanism is unclear, long-acting GnRH analogue should be considered as a possible therapy for gelastic seizures in patients with hypothalamic hamartomas.