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Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE
H R Morris1, J R Vaughan, S R Datta
1Neurogenetics Section, University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK.
Neurology
|January 3, 2001
Abstract:
Article abstract-Alpha synuclein, tau, synphilin, and APOE genotypes were analyzed in patients with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) and controls. The predisposing effect of the tau insertion polymorphism to the development of PSP is confirmed. However, no effect of alpha-synuclein, synphilin, or APOE variability on the development of PSP, or of tau, alpha-synuclein, APOE, or synphilin gene variability on the development of MSA, are demonstrated.