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Related Experiment Videos

Low-grade systemic inflammation in overweight children.

M Visser1, L M Bouter, G M McQuillan

  • 1Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands.

Pediatrics
|January 3, 2001
PubMed
Summary

Overweight children aged 8-16 show increased markers of inflammation, specifically higher C-reactive protein and white blood cell counts. This suggests a link between excess weight and low-grade systemic inflammation in pediatric populations.

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Area of Science:

  • Pediatric Endocrinology
  • Immunology
  • Public Health Nutrition

Background:

  • Human adipose tissue releases proinflammatory cytokines like interleukin-6, potentially causing systemic inflammation in individuals with excess body fat.
  • Previous research suggests a link between excess body fat and inflammation, but confounding factors like inflammation-related diseases need consideration.

Purpose of the Study:

  • To investigate the association between overweight status and low-grade systemic inflammation in children.
  • To determine if overweight children exhibit elevated markers of inflammation compared to normal-weight children, controlling for potential confounders.

Main Methods:

  • Utilized data from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994, a representative sample of US children aged 8-16.

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  • Assessed systemic inflammation through serum C-reactive protein (CRP) concentration and white blood cell (WBC) count.
  • Defined overweight status using body mass index (BMI) and sum of three skinfolds exceeding the 85th percentile for gender and age.

    • Main Results:

    • Overweight boys and girls were significantly more likely to have elevated CRP levels compared to their normal-weight peers.
    • Odds ratios for elevated CRP were 3.74 for overweight boys and 3.17 for overweight girls (based on BMI).
    • Overweight status was also associated with statistically significant higher white blood cell counts in children.

    Conclusions:

    • Overweight children aged 8 to 16 years exhibit higher concentrations of CRP and elevated WBC counts.
    • These findings indicate a state of low-grade systemic inflammation in overweight children, highlighting potential health risks associated with pediatric obesity.