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Related Experiment Videos

Postnatal changes in neonatal acylcarnitine profile.

J Meyburg1, A Schulze, D Kohlmueller

  • 1Department of Neonatology, University Children's Hospital, 69120 Heidelberg, Germany.

Pediatric Research
|January 3, 2001
PubMed
Summary
This summary is machine-generated.

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Electrospray-tandem mass spectrometry revealed significant changes in neonatal carnitine metabolism. Acylcarnitine levels rise post-birth, impacting fatty acid oxidation and potentially indicating perinatal issues.

Area of Science:

  • Biochemistry
  • Neonatal Metabolism
  • Mass Spectrometry

Background:

  • Neonatal carnitine metabolism is crucial for fatty acid oxidation.
  • Electrospray-tandem mass spectrometry (ES-MS/MS) is effective for detecting metabolic disorders.

Purpose of the Study:

  • To investigate changes in neonatal carnitine metabolism using ES-MS/MS.
  • To assess the relationship between carnitine profiles, birth weight, and perinatal conditions.

Main Methods:

  • Analyzed acylcarnitine concentrations in dried blood spots from neonates.
  • Compared samples from umbilical cord and postnatal day 5.
  • Included healthy, preterm, and small-for-gestational-age infants.

Main Results:

Related Experiment Videos

  • Most acylcarnitine species significantly increased by postnatal day 5.
  • Free carnitine levels remained stable, but the acylcarnitine/free carnitine ratio rose.
  • Lower umbilical artery pH correlated with increased long-chain acylcarnitines.

    • Conclusions:

    • Elevated acylcarnitines post-birth may impact fatty acid oxidation, relevant in conditions like sepsis.
    • Carnitine profiles are linked to birth weight.
    • Long-chain acylcarnitines may serve as biomarkers for perinatal asphyxia.